Cell Symposia: Mitochondria
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Early studies of mitochondria focused on their bioenergetic role, but we now appreciate the importance of these organelles in a wide range of cellular functions and signaling events. The development of animal models, systems-based approaches and dynamic imaging techniques are proving critical in unravelling the significance and complexity of mitochondrial behaviour.

This symposium will capitalize on the growing excitement about the diversity of mitochondrial functions and will include the following topics: mitochondrial dynamics and interactions with other organelles; signaling at mitochondria; diseases arising from mitochondrial dysfunction; mitophagy and mitochondrial quality control; and metabolism and bioenergetics. With this range of topics, which examines mitochondria from a cell biology, mechanistic, and disease perspective, we aim to bring together biologists from various disciplines, facilitating a wide-ranging discussion of emerging themes in mitochondrial biology.

Final Program

Sunday 5th May
12:00 Registration |White Plains Foyer
14:00-14:15 Welcome and Introduction | White Plains 3,4,5
Session 1: Signaling and mitochondria | White Plains 3,4,5
Session Chair: Richard Youle, National Institutes of Health, USA
14:15-14:45 Rosario Rizzuto, University of Padua, Italy
Molecular identity, regulation and function of the mitochondrial calcium uniporter, IS1.1
14:45-15:15 Navdeep Chandel, Northwestern University, USA
Mitochondria regulate differentiation through production of ROS, IS1.2
15:15-15:30 Zhirong Shen, National Institute of Biological Science, China
Mitochondria are important targets of necrosis-inducing RIP3 kinase complex, O1.1
15:30-16:00 Tea/coffee | New Orleans 1,2,3 & Nashville Room
16:00-16:30 Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
The mitochondrial pathway of antiviral innate immune response, IS1.3
16:30-16:45 Jerry Edward Chipuk, Mount Sinai School of Medicine, USA
Cellular addiction to oncogenic signaling suppresses mitochondrial function, O1.2
16:45-17:15 Poster teasers
17:15-19:30 Poster session I and Drinks Reception | New Orleans 1,2,3
Monday 6th May
Session 2: Mitochondrial dynamics | White Plains 3,4,5
Session Chair: Heidi McBride, McGill University, Canada
9:00-9:30 Janet Shaw, University of Utah, USA
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission, IS2.1
9:30-10:00 Gia Kaarina Voeltz, University of Colorado at Boulder, USA
3-D architecture of ER-mediated mitochondrial constriction sites in mammalian cells, IS2.2
10:00-10:15 Daniel Irimia, Harvard University, USA
Segregation of cancer cell motility phenotype based on the asymmetric mitochondria localization inside cells, O2.1
10:15-10:45 Tea/coffee | New Orleans 1,2,3 & Nashville Room
10:45-11:15 Luca Scorrano, University of Padova, Italy
Mitochondrial cristae shape determines assembly of respiratory chain supercomplexes, efficiency of respiration and of cell growth, IS2.3
11:15-11:45 Jodi Nunnari, University of California Davis, USA
ER-associated division links the distribution of mitochondria and mitochondrial DNA, IS2.4
11:45-12:00 Chris Meisinger, Institute for Biochemistry, Germany
Phosphoproteome of the mitochondrial outer membrane reveals signaling pathways regulating mitochondrial protein biogenesis, O2.2
12:00-13:00 Lunch | New Orleans 1,2,3 & Nashville Room
13:00-15:00 Poster session II | New Orleans 1,2,3
Session 3: Metabolism and Bioenergetics | White Plains 3,4,5
Session Chair: Eileen White, Rutgers University, USA
15:00-15:30 Paolo Bernardi, University of Padova, Italy
Dimers of mitochondrial ATP synthase form the permeability transition pore, IS3.1
15:30-16:00 Jean-Claude Martinou, University of Geneva, Switzerland
Role of the mitochondrial pyruvate carrier in cell metabolism, IS3.2
16:00-16:15 Carsten Merkwirth, Salk Institute for Biological Studies, USA
An epigenetic switch determines ETC-mediated longevity and mitochondrial stress signaling, O3.1
16:15-16:45 Tea/coffee | New Orleans 1,2,3 & Nashville Room
16:45-17:15 Marcia Haigis, Harvard University, USA
Mitochondrial sirtuins at the center of cellular signaling, IS3.3
17:15-17:45 José Antonio Enriquez, Centro Nacional de Investigaciónes Cardiovasculares Carlos III, Spain
Physiological role for the superassembly of the respiratory mitochondrial electron transport complexes, IS3.4
17:45-18:00 John C. Schell, University of Utah, USA
A role for the mitochondrial pyruvate carrier in cancer metabolism, O3.2
19:00 Meet the Speakers Dinner | Rio’s Restaurant Bar
Tuesday 7th May
Session 4: Mitochondria and Disease | White Plains 3,4,5
Session Chair: Jean-Claude Martinou, University of Geneva, Switzerland
9:00-9:30 Mohanish Deshmukh, University of North Carolina, USA
Cytochrome c degradation: A novel survival mechanism for neurons and brain tumor cells, IS4.1
9:30-10:00 Anu Suomalainen, University of Helsinki, Finland
Lost in interpretation: Mitochondrial dysfunction signals lead to irrelevant tissue responses and contribute to tissue-specific disease manifestations, IS4.2
10:00-10:15 Nuno Raimundo, Universitatsmedizin Goettingen, Germany
Tissue-specificity of mitochondrial pathology is determined by the AMPK-autophagy pathway, O4.1
10:15-10:45 Tea/coffee | New Orleans 1,2,3 & Nashville Room
10:45-11:15 Kinya Otsu, King's College London, UK
Mitochondrial DNA, inflammation and heart failure, IS4.3
11:15-11:45 Eileen White, Rutgers University, USA
Autophagy maintains mitochondrial function and tumorigenesis, IS4.4
11:45-12:00 David F. Kashatus, University of Virginia, USA
Mitochondrial fission is required for ras-driven tumorigenesis, O4.2
12:00-13:00 Lunch | New Orleans 1,2,3 & Nashville Room
13:00-15:00 Poster session III | New Orleans 1,2,3
Session 5: Mitophagy and Quality Control | White Plains 3,4,5
Session Chair: Luca Scorrano, University of Padova, Italy
15:00-15:30 Richard Youle, National Institutes of Health, USA
Roles of Pink1 kinase and Parkin E3 ligase in mitophagy and Parkinson's disease, IS5.1
15:30-16:00 Heidi McBride, McGill University, Canada
Mitochondrial dynamics and quality control, IS5.2
16:00-16:15 Doris Germain, Mount Sinai School of Medicine, USA
Stress in the inter-membrane space activates novel mitochondrial unfolded protein responses, O5.1
16:15-16:45 Tea/coffee | New Orleans 1,2,3 & Nashville Room
16:45-17:15 Thomas Langer, University of Cologne, Germany
Mitochondrial proteases, membrane dynamics and neurodegeneration, IS5.3
17:15-17:45 Ze'ev Ronai, Sanford-Burnham Medical Research Institute, USA
Control of mitochondrial dynamics by the ubiquitin ligase Siah2, IS5.4
17:45-18:00 Konstanze F. Winklhofer, Ludwig Maximilians University
The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO, O5.2
18:00-18:15 Closing remarks